
Black Guard
- Allies
- Clu, Jarvis, Rinzler
- Enemies
- Defined by Clu, their master
An extremely elite corps inside the Grid that ensure all programs follow Clu's directives. His personal guard.

Castor
- Actor
- Michael Sheen
- Allies
- Gem
Castor is a vivacious and well-known program in the Grid who runs the End of Line Club at the top of the tower in Tron city.

Clu
- Actor
- Jeff Bridges
- User
- Kevin Flynn
- Allies
- Jarvis, Rinzler, Black Guard, Sentries
- Enemies
- Programs defying system rules
Clu was originally a search program created by Kevin Flynn to explore inside the ENCOM mainframe for proof he created ENCOM's most-popular games. Clu was found and destroyed by the Master Control Program. Flynn created another program named CLU after returning from the Grid with a more specific task in mind...

Gem
- Actress
- Beau Garrett
- Allies
- Castor, Sirens
Gem belongs to a group of programs known as Sirens. Her function, as with all Sirens, is to prepare programs for the games by providing fitted armor — and in Sam Flynn's case — an identity disc.

Jarvis
- Actor
- James Frain
- Allies
- Clu, Rinzler, Black Guard, Sentries
- Enemies
- Defined by Clu
Clu's right-hand program and chief intelligence officer.

Quorra
- Actress
- Olivia Wilde
- Allies
- Kevin Flynn, Sam Flynn
- Enemies
- Clu, Jarvis, Black Guard, Sentries
A program, adept warrior, and confidante of Kevin Flynn's in the TRON System.

Rinzler
- Actor
- Dan Shor
- Allies
- Clu, Jarvis, Black Guard, Sentries
- Enemies
- Defined by Clu
Rinzler is an exceptionally skilled warrior and the elite combatant in all games in the Grid. He takes his commands from Clu.